Pioneering 3D Cell Culture and Disease Modeling for Predictive Compound Screening


At Bioprinting Laboratories Inc., we are at the forefront of innovation in 3D cell culture and organoid-based disease modeling. Utilizing our cutting-edge proprietary pillar/perfusion plate platform and advanced microarray 3D bioprinting technology, we deliver robust solutions for dynamic 3D cell culture applications. Our revolutionary microarray 3D bioprinting technology facilitates precise robotic deposition of human cells in hydrogels on our unique pillar plates. These plates, when integrated with our perfusion plates, enable superior cell growth by enhancing molecular diffusion and assay reproducibility. This platform stands out by offering high throughput, user-friendly operation, and reliable results. Human mini-tissues (or organoids) generated from pluripotent stem cells on our pillar plates provide a predictive and scalable platform for screening drug candidates and chemicals. These organoids support various applications in pharmaceutical, cosmetic, and chemical industries. By addressing the limitations of traditional organoid culture such as low throughput and lack of reproducibility, our innovative approach bridges a critical gap in preclinical evaluations. By offering seamless integration of robust organoid culture, in situ imaging, and predictive compound screening, our technology is transforming in vitro disease models to better reflect human biology. This ultimately accelerates the development of safer and more effective therapeutic solutions, setting new standards in research and industry practices.


Pillar Plate Technology

Our proprietary pillar plate platform transforms drug screening processes by enabling the scalable production of uniform 3D spheroids and organoids in a high-throughput format. Through versatile methodologies, including pillar plate stamping and advanced microarray 3D bioprinting, we empower pharmaceutical and biotech companies to evaluate drug candidates with exceptional efficiency and precision. Engineered in 36-, 144-, and 384-pillar formats, the pillar plates are designed to align seamlessly with the footprint of standard 384-well plates. This ensures full compatibility with existing laboratory equipment, including automated fluorescence microscopes and microtiter well plate readers, a pivotal feature for effective compound screening workflows. By bridging innovation with practical integration, our platform accelerates the pace of drug discovery while enhancing accuracy and reliability in preclinical evaluations.
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Perfusion Plate Technology

Our patented perfusion plate platform serves as an innovative complement to the pillar plate, offering a continuous bi-directional flow of cell culture media. This dynamic flow significantly enhances organoid growth and functionality, while effectively reducing necrotic core formation—creating an in vivo-like environment without relying on external pumps or tubes. Tailored for high-throughput dynamic 3D cell cultures, the perfusion plates are available in 36- and 144-well formats. These formats feature a 6 x 6 or 12 x 12 array of perfusion wells seamlessly integrated with corresponding reservoir arrays, all connected via precisely engineered microchannels. This sophisticated system empowers researchers to achieve improved reproducibility and scalability in advanced cell culture applications, paving the way for groundbreaking discoveries.
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Microarray 3D Bioprinting Technology

Our microarray 3D bioprinting technology revolutionizes organoid production with its micro-solenoid valve-driven, high-precision robotic cell printing system. This advanced system is engineered to rapidly and reproducibly create human organoids while minimizing manual intervention. At Bioprinting Laboratories Inc., we have pioneered and commercialized the integration of organoid printing and culture within a high-throughput pillar/perfusion plate platform. This innovation paves the way for scalable, automated drug discovery applications, transforming the future of pharmaceutical and biotech research.
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Applications


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Scale-up organoid production
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Co-culture
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Organoid cryopreservation

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Liver toxicity
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Developmental neurotoxicity
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Anticancer drug screening

Why Choose Our Technology?


  • 10-100x assay miniaturization Significant cost reduction in drug screening

  • Enhanced organoid maturity by dynamic cell culture More physiologically relevant data

  • Compatible with standard laboratory equipment such as microtiter well plate readers and fluorescence microscopes Seamless laboratory integration for high-throughput applications

  • User-friendly design Pump-free, dynamic cell culture without expensive equipment necessary

Supporting Evidence


  • Peer-reviewed articles featuring our technology.

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