Microarray Technology - Bioprinting Laboratories Inc. (or BPL)

How Microarray 3D Bioprinting Technology Works

Bioprinting Labs has developed microarray 3D bioprinting technology, leveraging micro-solenoid valve-driven robotic cell printing methods to enhance automation and scalability. This innovative technology enables rapid and precise cell deposition onto pillar plates, optimizing organoid formation and culture. Additionally, it facilitates high-throughput compound screening, significantly advancing research capabilities.

High-precision, miniature cell printing: Utilizes micro-solenoid valves for layer-by-layer cell patterning.
Rapid organoid formation: Automates the bioprinting of expandable organoids, reducing variability and manual labor.
Scalable high-throughput screening: Enables rapid testing of various culture conditions and drug combinations.
On-chip, in situ imaging: Aligns within the focus depth of standard microscope objectives (4x and 10x), ensuring straightforward image acquisition.

Innovative Solutions with Microarray 3D Bioprinting

Publications

Shrestha, S., Vanga, M.G., Jonnadula, C., Acharya, P., Lee, M.S., and Lee, M.Y., Reproducible, scale-up production of human liver organoids (HLOs) on a pillar plate platform via microarray 3D bioprinting, Methods in Molecular Biology entitled Organoids: Stem Cells, Structure, and Function, Second Edition, DOI: 10.1007/7651_2024_603 (2025)

Lekkala, V.K.R., Shrestha, S., Qaryoute, A.A., Dhinoja, S., Acharya, P., Raheem, A., Jagadeeswaran, P., and Lee, M.Y., Enhanced maturity and functionality of vascular human liver organoids through 3D bioprinting and pillar plate culture, ACS Biomaterials Science & Engineering, doi.org/10.1021/acsbiomaterials.4c01658 (2025)

Shrestha, S., Lekkala, V.K.R., Acharya, P., Kang, S.Y., Vanga, M.G., and Lee, M.Y., Reproducible generation of human liver organoids (HLOs) on a pillar plate platform via microarray 3D bioprinting, Lab on a chip, DOI: 10.1039/D4LC00149D (2024)